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Numerous ideas on the genesis of this disease have emerged, with several theories dominating at different historical intervals

Moreover, it remains unclear why equal decreases occur in nuclei [173]

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Following from previous work that sought to identify sequence determinants of S fibrillation, a library-based -lactamase tripartite fusion construct in which S was inserted between Blac fragments and probed for aggregation, identified mutations within the P1/P2 regions that impacted on the ability of S to aggregate