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ROS can only be formed in the presence of O2, which means upon reperfusion

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Imai H, Hakkaku N, Iwamoto R, Suzuki J, Suzuki T, Tajima Y, Konishi K, Minami S, Ichinose S, Ishizaka K, et al

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( In fact, others have also found that targeting antioxidant capacity using different interventions such as methylcobalamin, folinic acid ( Significant improvements in the glutathione levels of children with ASD were also confirmed in this study using a nutritional approach known to increase glutathione biosynthesis