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These mediators directly participate in pathogen clearance and activate the expression of pro-inflammatory factors, creating a positive feedback loop with pro-inflammatory cytokines ( IL-15 , IL-10 , TNF- , CASP3 , and CASP9 (Yang et al., 2019)

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Disturbed genomic integrity induces oxidative genetic damage, DNA oxidation, the activation of proto-oncogenes, and the inactivation tumour suppressor genes leading to proliferative effects and mutagenesis (113, 114)

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The remaining authors declare that they have no conflicts related to the content of this article