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Beyond its translational potential, this work offers fundamental insights into the neural substrates of stress hypersensitivity in ASD, positioning CCK as both a potential biomarker and a therapeutic target

Nat Commun 2017;8:15074

Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded

Oral and topical forms may have some effect in specific cases

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Since APX is widely distributed and has a better affinity for H 2 O 2 than CAT, it is a more efficient scavenger of H 2 O 2 at times of stress