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Additionally, CD117 is expressed at high levels in OCSCs and plays a role in tumor initiation and resistance to cisplatin/paclitaxel by activating the Wnt/-catenin-ABCG 2 pathway (76)

TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) is a transmembrane receptor that is activated by a variety of ligands including lipids (Cannon et al., 2011

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doi: 10.1182/blood-2005-06-2538 78 ChangLKGarcia-CardeaGFarneboFFannonMChenEJButterfieldCet al

The shared host-cell adhesion and haem-binding functionality of many NTHi proteins suggests that bacterial haem-utilisation plays an important role in its interplay with host epithelial cells and may provide an adaptive advantage for colonisation in environments with low haem-iron availability ( 4.2 Survivability and virulence in the respiratory tract Continued NTHi survival in the respiratory tract requires a secure source of host-derived haem