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N-methylthiourea is proposed to be the main methimazole reactive metabolite responsible for the hepatotoxicity induced by this drug.36 But, we recently showed that glyoxal also might has an important role in cellular injury induced by methimazole in an in vitro model of isolated rat hepatocytes.41 PTU is metabolized by glucuronidation in liver and prepared to exert from body (Fig
The manufacturers can also stuff the vials with filler without telling consumers what they are using
The cost calculation is straightforward: a $3 vial of bacteriostatic water saves hundreds of dollars in peptide waste
Chen Y, Guo J, Wu X, et al
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