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CV safety is currently under investigation for tirzepatide in patients with obesity without diabetes (NCT05556512) and for cagrilintide/semaglutide with overweight and obesity with and without diabetes (NCT05669755)

[DOI] [PubMed] [Google Scholar] 132.Ashpole N.E., Overby D.R., Ethier C.R., Stamer W.D

The many roles of histone deacetylases in development and physiology: implications for diseases and therapy

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Complement activation promotes colitis-associated carcinogenesis through activating intestinal IL-1beta/IL-17A axis

Studied in models involving GLP-1 receptor activity, incretin signaling, glucose-response biology, and metabolic regulation
