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Discussion Currently, decades of target exploration and hundreds of clinical trials have resulted in failure, though the first drug, resmetirom has just been approved for the management of metabolic dysfunction-associated steatohepatitis [15,16,36]

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is supported by the NUHS Internal Grant Funding under NUS Start-up grant NUHSRO/2022/047/Startup/11, an MOE Tier 2 grant T2EP30124-0014, and a Vidi grant from the Netherlands Organization for Scientific Research (NWO

J Endocrinol Invest 39(4):357373 Kohn DB, Hershfield MS, Puck JM, Aiuti A, Blincoe A, Gaspar HB, Notarangelo LD, Grunebaum E (2019) Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency