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Under the stimulation of lipopolysaccharide (LPS) and IFN- or IL-4, naive macrophages differentiate into M1 or M2 macrophages

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[99] Overdose [edit] Clomipramine overdose usually presents with the following symptoms: [19] [21] [22] Signs of central nervous system depression such as: stupor coma drowsiness restlessness ataxia Mydriasis Convulsions Enhanced reflexes Muscle rigidity Athetoid and choreoathetoid movements Serotonin syndrome - a condition with many of the same symptoms as neuroleptic malignant syndrome but has a significantly more rapid onset Cardiovascular effects including: arrhythmias (including Torsades de pointes) tachycardia QTc interval prolongation conduction disorders hypotension shock heart failure cardiac arrest Apnoea Cyanosis Respiratory depression Vomiting Fever Sweating Oliguria Anuria There is no specific antidote for overdose and all treatment is purely supportive and symptomatic

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