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The supernatant was removed, sodium azide (0.3%) added and then finally 0.1 mM 1,2-diaminobenzene was added for derivatisation over 4 h

The liver is vulnerable to damage from the oxidative stress caused by alcohol metabolism

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Although the effect of mB12/LDFA and BH4 on methylation and glutathione metabolism have been examined in the open-label studies, these changes have not been compared to controls who received a placebo in order to account for the natural variation in the changes in these pathways

GLS inhibitors, such as CB-839, have been shown to impair GSC survival by inducing metabolic stress and triggering the amino acid deprivation response pathway, thereby increasing their susceptibility to chemotherapy

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