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CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD(+) and NMN levels

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In contrast, DIO mice in both groups switched from WD to LD each had significantly increased Proteobacteria relative abundance (represented solely by the genus Parasutterella ) compared to both the WD and the LD controls, suggesting that Proteobacteria relative abundance may be largely influenced by stress or the differences in net energy expenditure (or associated body weight changes) caused by the diet switch

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GIP receptor agonism further enhances insulin release and may improve fat metabolism