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Additionally, oxidative stress-induced lipid peroxidation compromises membrane integrity, increasing cellular permeability, and perpetuating inflammatory signaling 124

G8090, G8091, G8093, G8092

Lactate secreted by CRC cells promotes the polarization of TAMs toward an M2-like immunosuppressive phenotype, impairs CD8 T cell function, and reduces the efficacy of ICIs [126]

Ethics declarations Conflict of interest All procedures performed in this work involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards

In those experiments where using contact co-culture model was not possible, hECs received 50% conditioned medium from PCs to promote brain-like properties