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Longitudinal melanonychia refers to a pigmented stripe or band along the length of a nail (finger or toe)

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The initial signs and symptoms often include a lesion that is soft to palpation, usually pigmented, initially asymptomatic, with irregular borders and a color spectrum ranging from dark brown to bluish-black, occasionally presenting variations of gray, purple, and red due to ulcerations, or depigmentation (Figure 5) [39,40]

Adipose stem cell-derived exosomes ameliorate chronic rotator cuff tendinopathy by regulating macrophage polarization: from a mouse model to a study in human tissue