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thus, they have a dual mechanism of action

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T cells consist of two main functionally separate types: CD4 + helper T cells (Th cells) and CD8 + cytotoxic T lymphocytes (CTLs)

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The elevated levels of Glu in the diabetic vitreoretinal are thought to be mediated by the dysfunction of glutamate transporters on retinal Mller cells and possibly, due to the decreased expression of glutamine synthase (Li and Puro, 2002