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Comprehensive metabolic improvement is needed

This series of novel therapeutic regimens has spurred the development of triplet regimens

BPC-157 Essential for gut healing, as intestinal permeability and dysbiosis are common in metabolic disease states and contribute to systemic inflammation, brain fog, and fatigue through the gut-brain axis

According to the estimates provided by World Health Organization (WHO) in 2019, cancer is already the first or second cause of death before the age of 70 in 112 of 183 countries and its prevalence is expected to increase ( In addition to surgery and radiation, chemotherapy which uses broad-spectrum cytotoxic drugs that do not differentiate cancer cells from normal cells, remains as the main arm of cancer treatment, despite its toxicity and significant side effects ( By the turn of the millennium, insights into the genomic landscapes of cancers led to the development of drugs that selectively target cancer cells while sparing normal cells, hence having high potency and fewer adverse effects ( Owing to the clinical success of platinum drugs in a wide range of cancers and the requirement for reduction of treatment costs, there has been renewed interest in the development of novel metallodrugs in the field of inorganic drug development ( Considering the reduction of development costs and affordability as a priority, repurposing old metal binding drugs to form complexes with Cu to selectively target cancer cells has been rigorously investigated in the past years ( Here, we review the roles for Cu in cancer progression and the potential of harnessing copper homeostasis pathways in cancer cells with the Cu-binding activity of DSF and its derivatives, with a focus on recent developments in the translation of DSF for cancer therapy