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The maintenance dose of levothyroxine is approximately 1.6 mcg/kg/day, considered a full replacement dose

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These phosphorylated R-SMADs form complexes with cytosolic SMAD4 and translocate to the nucleus, regulating gene expression that results in G1 cell cycle arrest and apoptosis in early-stage PCa cells (Jones et al., 2009)

Fatigue is another consideration at higher doses

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Injuries can be open or closed