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While acute administration of opioids into the PAG disrupts the activity of on- and off- cells in response to painful stimuli, these cells respond normally following chronic infusion that is associated with tolerance (Lane et al., 2004)

2.2 Regulating the expression of factors involved in glucose metabolism SIRT2, a member of the sirtuin family, plays a crucial role in metabolic homeostasis through post-translational modifications of target proteins, influencing gene expression and signal transduction pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.ukasz B., Rybakowska I.M., Krakowiak A., Anand J.S

Potential contribution of NF-kappaB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury

Anti-depressant effects of Gastrodia Elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling