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Testing with fresh pharmaceutical grade product can distinguish between these possibilities

Improvements usually begin within 12 weeks of initiating treatment

Consistent handling in research settings

For advanced osteoarthritis involving the entire joint, supplement local injections with a systemic abdominal injection (split the daily dose)

Ensuring adequate vitamin C status supports the collagen deposition that constitutes much of connective tissue repair

Acknowledgements This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HH21C0004), and a National Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT (MSIT) (NRF-2020R1F1A1072720)