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These findings are consistent with the NMDA-R hypofunction model

Unlike sudden hair loss conditions, androgenetic alopecia typically progresses slowly over months to years, allowing time for treatment initiation

doi: 10.1016/S2213-2600(20)30448-3 252 AnderssonAMAnderssonBLorellCRaffetsederJLarssonMBlomgranR

Chem Med Chem

10.1167/iovs.05-1395 26 FariaB

The latest findings further revealed that the HECT domain-containing ubiquitin E3 ligase HUWE1 was also an underlying protective modulator that could combat ferroptosis and abnormal iron accumulation by diminishing the amassing of TfR1, reducing the risk of ALF (Wu et al., 2022)