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Description
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In response to increased plasma Hcy concentrations, there may be vascular endothelial dysfunction, reduced expression of thrombomodulin and activated protein C [64], a decrease in the presence of anticoagulant heparans [65], and a decrease in tissue plasminogen activator receptors on the surface of vascular endothelial cells [66]
The auxiliary nucleotide binding site is buried deep within the SD and is inaccessible to the solvent
The Lancet Frias JP, et al
