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Several of these metabolites have already been explored as candidate biomarkers and therapeutic targets in preclinical studies [165]

Crawford, B

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For example, synovial macrophages from patients with ACPA-negative RA exhibit reprogramming of multiple amino acid metabolic pathways, and this metabolic phenotype is closely linked to disease progression ( In IBD, intestinal mucosal macrophages play a key role in maintaining intestinal immune homeostasis and inflammatory responses, and their functional states are markedly influenced by metabolic reprogramming

Biochemical pharmacology of disulfiram

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