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Possessing stem-like properties, tumor-repopulating cells (TRCs) develop therapeutic resistance to both chemotherapy and irradiation through mechanisms that reduce their susceptibility to ferroptotic cell death (81)

1f), and distinct from the ECD orientation of CTR-Gs bound to sCT (Fig

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Then we designed shRNA targeting the ATG10 gene, an E2-like enzyme involved in autophagy that catalyzes the conjugation of ATG12 to ATG5 ( ATG10 expression level revealed that the affinity cell sorting led to a significantly increased shRNA knockdown efficiency of 60% in the sorted cells, compared to a knockdown efficiency of 7% in the before sorting cells (Figure 5B)

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