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meaning that animal studies have shown some adverse effect or there are no well-controlled studies in humans, but potential benefits may warrant use despite potential risks

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As a result, CSF dopamine levels do not accurately indicate CNS dopamine deficiency Simultaneously, although changes in HVA in the striatum are not fully consistent with dopamine levels, DOPAC is a major metabolite of dopamine, suggesting that DOPAC in the CSF is more suitable for use as a diagnostic indicator of PD than dopamine and HVA (Landau et al., 2022)