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Air pollutants (PM2.5, NO), heavy metals (lead, cadmium), and microplastics have each been associated with excessive ROS production, that leads to lipid peroxidation, mitochondrial dysfunction, and sperm DNA fragmentation (22)

Cardiovasc Res 1998

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This phenomenon is known as induced systemic resistance (ISR) (Pieterse et al., 2014)

Although the use of targeted metabolite tracing, such as deuterium tracing of NADPH [7], is successful and remains the gold standard in the field, this approach requires mass-spectrometry, which may not be accessible to many laboratories