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A nested case-control study within the Singapore Chinese Health Study demonstrated a significant 57% reduction in colon cancer risk among high consumers of dietary isothiocyanates (ITCs) who carried the double null genotype, suggesting that compromised GST activity enhances the protective effect of ITCs like SFN (59)

Various structurally related analogs to BN-82451 include LY-178002, LY-256548, ONO-144, and MK-477

Retrieved May 24, 2022, from [10] Pfizer Announces Positive Top-line Results from Yearlong Phase 3 Trial of Etrasimod in Ulcerative Colitis, Underscoring Best-in-Class Potential

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For instance, curcumin significantly reduced histopathological damage and improved general symptoms in experimental colitis, accompanied by increased the expression of Treg cells and decreased the expression of Th17 cells as well as increased the expression of anti-inflammatory cytokines such as IL-10 and decreased the expression of proinflammatory cytokines such as IL-17A, IL-1, IL-6, IL-33, CCL-2, IFN-, and TNF- [264, 266, 267]

J Exp Bot 66: 14271436 [DOI] [PMC free article] [PubMed] [Google Scholar] Mozos I, Stoian D, Caraba A, Malainer C, Horbaczuk JO, Atanasov AG (2018) Lycopene and vascular health