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Results A forward genetic screen identifies unc1 as a modulator of polyQ aggregation To expand our knowledge of the signalling pathways controlling protein homeostasis, we performed a chemical mutagenesis screen for genes regulating protein aggregation in a worm model of polyQ diseases

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L-carnitine was orally administered at a rate of 2 mg/day

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The corresponding AUC increased significantly from 0685 (0626, 0745) in the traditional risk factor model to 0769 (0716, 0822) when TMAO and its precursors were included (l-carnitine, betaine and choline) ( P = 0032)

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