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[6, 12] Tocilizumab, a humanized monoclonal antibody against the IL-1 and IL-6 receptors, was also used as these patients often had high levels of these cytokines

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Although the recommended time for diagnosis of congenital hypothyroidism and therapeutic intervention should be initiated between the first two and three weeks of life, the average treatment initiation time for the patients of this study was 19.7 4.72 months [19,20]

Although the precise reasons were unclear, it was speculated that the therapy only benefited those with definitive autoimmunity causing the ME/CFS symptoms

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