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Indications and Usage: Methotrexate is used to treat certain types of cancer or to control severe psoriasis or rheumatoid arthritis

Wang G, Zhao L, jiang Q, Sun Y, Zhao D, Sun M, et al

The Arg3 substitution replaces one amino acid (arginine at position 3), making the compound less likely to bind to IGF-binding proteins that normally deactivate IGF-1 in the bloodstream

doi: 10.3109/09286586.2014.988874

The identification and structural characterization of C7orf24 as -glutamyl cyclotransferase: an essential enzyme in the -glutamyl cycle
