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Lot CP-0002046 was tested by an independent laboratory
[PubMed] [Google Scholar] 25.Lenger S.M., Bradley M.S., Thomas D.A., Bertolet M.H., Lowder J.L., Sutcliffe S

[Google Scholar] 237.Gohil K.J., Patel J.A
This angiogenic effect appears to work through the upregulation of vascular endothelial growth factor (VEGF) and other growth factors critical for tissue repair

INTRODUCTION Oxidative stress results from an imbalance between reactive oxygen species production (ROS) and the abilities of biological systems to eliminate them

Notably, the combination of JHU083 plus anti-PD1 or JHU083 plus anti-PD1 plus anti-CTLA4 resulted in greater inhibition of tumor growth and enhanced survival, suggesting an additive effect of combining metabolic therapy with checkpoint blockade (Supplemental Figure 6, A and B)