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While cortisone is highly effective at quickly reducing inflammation and pain, it can cause issues with long-term use, such as tissue atrophy, weakened tendons, and blood sugar elevation

The American Diabetes Association (ADA) Standards of Care and American College of Physicians (ACP) guidelines support the use of GLP-1 receptor agonists, including dual agonists like tirzepatide, as effective options for glycemic control and weight management

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Therefore, both the cancer protection mechanism and the radio-resistance mechanism of GH and IGF1 are via their role in regulating cell proliferation and apoptosis