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Both 4hydroxyhexenal and 4hydroxynonenal at low concentrations are protective against oxidative stress by triggering the Nrf2 pathway, which regulates the expression of antioxidant proteins including heme oxygenase-1, a potent antioxidant enzyme, and they can induce other cytoprotective pathways and enhance expression of other detoxification genes

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This can lead to loss of biological activity, significantly limiting its use in nutraceutical applications. Microencapsulation, in contrast, provides a stable, comprehensive solution to astaxanthins chemical instability and sensitivity to oxidation. Gomez added the encapsulation of spirulina further enhances the antioxidant properties of astaxanthin, amplifying the benefits of both compounds

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For the year 1935-36, the budget for these purposes is $1,241,218.00