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72 In pancreatic -cells, it alleviates ER stress and promotes insulin secretion, whereas its deficiency accelerates oxidative damage and -cell failure

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Thus, continued transfer of electrons from NADH to molecular oxygen is necessary for maintaining the low NADH/NAD + ratio, which, in turn, allows the TCA cycle flux toward the biosynthesis of oxaloacetate

(96) were the first group to demonstrate that muscular exercise promotes radical production in both liver tissue and skeletal muscles