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Liver microenvironment The liver microenvironment is primarily composed of hepatic stellate cells (HSCs), hepatocytes, sinusoidal endothelial cells and various types of immune cells including metastasis-associated macrophages [97]

Am J Physiol 1991;261:H1053H1059

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Biochimie 94 (9), 18371848

Oxidative stress In -thalassemia, ineffective erythropoiesis results in increased hemolysis and the release of free hemoglobin, which further exacerbates oxidative stress through the Fenton reaction, where iron catalyzes the conversion of hydrogen peroxide into highly reactive hydroxyl radicals (76)

J Inorg Organomet Polym Mater 35:4774 Ameen SSM, Algethami FK, Omer KM (2025) Precisely engineered dual-antenna europium MOF with intrinsic dual-state luminescence for sensitive dexamethasone sensing