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In the context of viral replication, constraint-based modeling allows the simulation and prediction of the viral capacity to replicate within a host cell by considering nutrient availability, energy resources, and other cellular factors 16,17

Vit-Es antioxidant properties combat ROS and reduce MDA, with various studies indicating a correlation between OSMs, including MDA, and the severity of IBD (206)

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It amplifies the NAD + /NADH ratio, leading to decreased lactate and ROS levels, concurrently promoting increased ATP synthesis in fibroblasts affected by mitochondrial encephalopathy lactic acidosis and stroke-like episodes (MELAS) [514]

Within the same synthetic pathways for GSH production, adequate levels of several B vitamins are essential, as they serve as enzymatic cofactors in multiple metabolic pathways contributing to GSH synthesis: (i) vitamin B6 contributes to normal cysteine synthesis, regarded as the rate-limiting factor in GSH synthesis