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4h) as was the case in the gut (Fig
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Emerging evidence indicates that activation of the UPRmt in the liver acts as a key upstream mechanism controlling FGF21 expression and secretion, with the ATF4 signaling axis serving as the central pathway mediating this induction (Yuan et al., 2025)
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The substance-drug complex formed between the two components was stabilized via intermolecular hydrogen bonds, forming a synergistically developed water-soluble nanogel system
