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6-paradol could reduce the production of NO, IL-6, and TNF- in cultured BV-2 microglia cells by 20 ug/mL doses and prevent cell damage in mice by doses 10 mg/kg doses

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The gene showed low activity in stationary macrophages (M0), increases in pro-inflammatory differentiated cells (M1 macrophages), and decreases in cells differentiating into anti-inflammatory macrophages (M2 macrophages) (69)
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