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This study identified higher histone H3 lysine 9 trimethylation (H3K9me3) levels at the promoter of the gene encoding retinoic acid receptor (RAR)-related orphan receptor alpha ( RORA )

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This suggests a cooperative allosteric interaction, where the binding of both Neto2 and zinc induces a receptor conformation with higher efficacy than can be achieved by either modulator alone

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This deficiency has also been linked to gastroparesis in patients with type 2 diabetes [25]

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