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Summary: GLP-1 receptor agonists are not formally associated with leg cramps, but indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients

Critical Care Medicine 32 (3): 848-51
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Diabetologia 67 , 470482 (2024)

HHF Three trials (two with semaglutide 45,46 and one with tirzepatide 44 ) included patients with previously diagnosed heart failure