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The most relevant inhibitors reported in the article are LOX-5 inhibitors, including zileuton (Liu et al., 2015

Peripheral neuropathy: pathogenic mechanisms and alternative therapies

More people now are looking far beyond symptom management and asking a deeper question: Why does my body keep struggling to defend itself

Consequently, optimisation of nose-to-brain delivery is frequently achieved through a combination of targeted deposition in upper nasal regions and permeability-enhancing excipients as well as nanocarrier systems that protect the active pharmaceutical ingredient (API) from enzymatic degradation and facilitate mucosal transport (Chung et al., 2023, Dhuria et al., 2010, Illum, 2003)

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Precursors were fragmented by high-energy collision dissociation (HCD) at a normalised collision energy of 60% to ensure maximal TMT reporter ion yield