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[PubMed: 5541346] 6

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Additional biochemical assays were used to test the ability of compounds to inhibit nicotinamide phosphoribosyl transferase (NAMPT) and NAD + -dependent protein deacetylase sirtuin 1 (SIRT1), two enzymes in the NAD + biosynthesis/salvage pathway

However, side effects and complications can include: itchy skin low blood pressure slowed breathing loss of bladder control fever flushed chest or face anxiety difficulty sleeping changes in the menstrual cycle diarrhea nausea temporary increase in blood sugar In severe breathing difficulty nerve damage prolonged numbness abscesses bleeding allergic reaction adrenal suppression epidural bruising infection spinal headache pain in the lower limbs or back paralysis Doctors may use a nerve block spinal injection to treat acute or chronic pain that may originate in the spine and can radiate to the arms, legs, buttocks, and neck

Where available, supporting laboratory documentation can be provided upon request

Metabolism 47 : 14811489 Morrow LA et al