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System Xc - plays a critical role in maintaining the bodys levels of GSH by participating in glutamate release, cystine uptake, and GSH synthesis

doi:10.1146/annurev.cellbio.22.010305.104538

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Iron concentrations increase within the brain parenchyma during normal aging, but this is accelerated in PwMS and is more pronounced in those with progressive disease courses [169, 170]

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