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Although TRPA1 seems to play a crucial role in the cell death promoted by ischemia (de Arajo et al., 2020

82 , e11e14 (2021)

Therefore, a deficiency of glutathione plays a key role in aging and many disease states

Since neither GSH nor GSNO can directly bind to these promoters, this transcriptional activation presumably involved one or more TFs
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Dietary supplementation of GlyNAC could be developed as a simple, safe, and effective nutritional strategy to improve cellular aging and health of PWH
