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In the absence of an established cancer MOA, USEPA (USEPA 2005a) recommends using a linear low-dose extrapolation procedure for cancer risk assessment

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Bibcode:2013PLoSO...877257M

The 28% nausea rate is dramatically lower than Wegovys 44%, and the discontinuation rate of 11.2% is reasonable given the unprecedented efficacy
reprogramming macrophage phenotypes toward pro-healing M2 states

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