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Absence of expected improvement by mid-protocol (4-6 weeks) warrants reassessment

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Ferroptosis is characterized by the following key molecular events: (1) Elevated hepatic iron levels promote ROS generation (including hydroxyl radicals, singlet oxygen, and superoxide anions) via the Haber-Weiss and Fenton reactions [Table 2] [27,51,59,101-103]

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244,245,246 (vi) RNA nanoparticles (e.g., three way-junction, 3WJ)
21 (10), E3688