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Lipid-derived Signaling Molecules as Substrates of MRP1 The CysLT LTC 4 (and its extracellularly formed CysLT metabolites leukotriene D 4 and leukotriene E 4 ) are potent pro-inflammatory molecules derived from arachidonic acid through the 5-lipoxygenase/leukotriene C 4 synthase pathway (69) (Figs

In contrast, 80% of both male and female mice displaying lymphoma signs before 6 months of age (Fig
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A., Siegel, F
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