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The upregulation and activation of 7nAChR subsequently activate several signaling pathways, including neuroprotective PI3K/Akt and Nrf2 pathways, then suppression of pro-apoptotic caspase-3, and suppression of NF-B that reduce the expression of proinflammatory cytokines such as IL-1, and TNF- [50, 86]
2011 Jul 12 [cited 2024 May 28];5
The overall regulatory state of pyroptosis is shown in Fig
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It would be unexpected for CIPN to appear weeks or months after the last dose of neurotoxic chemotherapy treatment
