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The role of the GIP receptor in adipose tissue, however, remains complex and debated, with evidence suggesting it may promote lipid storage and nutrient partitioning into adipose tissue [12]

EGCG treatment can induce autophagy, as it diminishes the effect of negative regulators of autophagy such as GADD34, which controls apoptosis

This work was funded in part by a grant from Autism Speaks (grant number 7274) to J.V.W

Pediatr Cardiol 37(4):746750 Von Harsdorf R, Li PF, Dietz R (1999) Signaling pathways in reactive oxygen speciesinduced cardiomyocyte apoptosis

HFD-treated male heterozygous jvs /+ mice also exhibited NASH to a similar extent and severity, and the incidence of tumor formation was similar to what was observed in AL and HFD-treated male wild-type mice