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SIRT1 also increases the expression of MnSOD by deacetylating p53, thus enhancing cellular antioxidant capacity (Brunet et al., 2004

Jbara, M., Maity, S

& Carri, M

Patients with ER-positive tumors that expressed low levels of CDK10 , because of promoter methylation, relapsed early on tamoxifen treatment

Early mutagenesis studies of the Arabidopsis GS identified a putative glycine-rich loop as important for activity (Wang and Oliver, 1997a,b), which was identified in later structural studies as forming part of the active site (Galant et al., 2009)

Despite fertility-sparing therapy showing promising response, vigilance and consideration of surgical intervention are crucial post-relapse