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Regulation of gene expression by modulating microRNAs through Epigallocatechin-3-gallate in cancer

[DOI] [PubMed] [Google Scholar] 112.Ikawa M, Okazawa H, Tsujikawa T, Matsunaga A, Yamamura O, Mori T, Hamano T, Kiyono Y, Nakamoto Y, Yoneda M

Bhandari AP, Liong R, Koppen J et al (2021) Noninvasive determination of IDH and 1p19q status of lower-grade gliomas using MRI radiomics: a systematic review

As previously discussed, bacterial products, collectively known as PAMPs and MAMPs, derived from the gut, reach the liver via portal circulation and systemic circulation through the mesenteric lymph nodes, and may induce an inflammatory response by activating Toll-like receptors (TLRs)

Moreover, it enhances antigen presentation machinery in DCs and other APCs, promotes T-cell recruitment to tumor sites, and activates the JAK/STAT/IRF1 signaling pathway to induce direct cytotoxic effects on cancer cells [284,285,286,287]

306,307,308 Specifically, p53 inhibits glucose uptake and glycolysis, promoting a metabolic shift towards the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, thereby increasing sensitivity to cuproptosis