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In aged animal models, it has been established that reduced expression of key enzymatic and non-enzymatic antioxidants in Leydig cells can result in excessive oxidative stress, potentially leading to a decline in testosterone secretion [50]

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Martn M, Macas M, Escames G et al (2000a) Melatonin but not vitamins C and E maintains glutathione homeostasis in t-butyl hydroperoxide-induced mitochondrial oxidative stress

NiuEGaoSHuWZhangCLiuDShenGet al

The H 2 O 2 content increased by 154% in the roots and by 166% in the leaves of As-treated seedlings, compared with that of the untreated control

Parker G, Ricciardi T, Hadzi-Pavlovic D